Description

tert-Butyl 4-(Bromomethyl)-1H-Indole-1-Carboxylate is a versatile and high-value indole derivative, specifically functionalized with a bromomethyl group at the 4-position and protected with a tert-butyloxycarbonyl (Boc) group. This compound is a critical pharmaceutical intermediate and advanced building block in organic synthesis, prized for its dual reactivity which enables precise molecular construction. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those targeting neurological disorders and oncology.
• Boc-Protected Indole Chemistry: Serves as a protected scaffold for the stepwise synthesis of more elaborate indole-based molecules, where the Boc group can be selectively removed.
• Alkylation Reagent: The reactive bromomethyl moiety allows for efficient alkylation reactions, introducing the indole core into larger molecular frameworks.
• Cross-Coupling Reactions: Used in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form carbon-carbon bonds for constructing complex heterocyclic systems.
• Agrochemical Research: Building block for developing new crop protection agents and pesticides with novel modes of action.
• Material Science: Potential monomer or precursor for creating specialized polymers and organic electronic materials.

Basic Information

Product Name	tert-Butyl 4-(Bromomethyl)-1H-Indole-1-Carboxylate
CAS No.	220499-13-8
Molecular Formula	C14H16BrNO2
Molecular Weight	310.19 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 4-(bromomethyl)-, 1,1-dimethylethyl ester; 4-(Bromomethyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(bromomethyl)indole-1-carboxylate; Boc-4-(bromomethyl)indole; 1-Boc-4-(bromomethyl)indole; 4-Bromomethyl-1-Boc-indole; 220499-13-8; BOC-4-BROMOMETHYLINDOLE
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Bromomethyl)-1H-Indole-1-Carboxylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data to support your R&D and scale-up activities. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.