Description

tert-Butyl 4-(Hydroxymethyl)-1H-Indole-1-Carboxylate is a high-value, protected indole derivative that serves as a critical synthetic intermediate in advanced organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, offering both a reactive hydroxymethyl group and a tert-butoxycarbonyl (Boc) protecting group for the indole nitrogen. Pharmaceutical research and development laboratories need it for the efficient synthesis of novel drug candidates, particularly in the fields of oncology and neurology, where indole-based structures are prevalent.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potent, biologically active indole alkaloids and small-molecule drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in constructing linker components that connect E3 ligase ligands to target protein binders.
• Chemical Biology Research: Serves as a precursor for fluorescent probes or activity-based protein profiling (ABPP) agents targeting indole-binding proteins.
• Agrochemical Synthesis: Intermediate in the development of new generation plant growth regulators or fungicides with indole cores.
• Material Science Precursor: Potential monomer or cross-linking agent in the synthesis of specialized polymers with unique optical or electronic properties.
• Academic & Contract Research: Essential reagent for methodology development and complex natural product synthesis in university and CRO laboratories.

Basic Information

Product Name	tert-Butyl 4-(Hydroxymethyl)-1H-Indole-1-Carboxylate
CAS No.	220499-12-7
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 4-(hydroxymethyl)-, 1,1-dimethylethyl ester; 1-Boc-4-(hydroxymethyl)indole; 4-(Hydroxymethyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(hydroxymethyl)indole-1-carboxylate; Boc-4-hydroxymethylindole; N-Boc-4-(hydroxymethyl)indole; 4-Hydroxymethyl-1-Boc-indole
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Hydroxymethyl)-1H-Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.