Description

S-[2-(N7-Guanyl)Ethyl-D4]GSH is a deuterium-labeled isotopologue of S-[2-(N7-guanyl)ethyl]glutathione, a critical biomarker adduct formed from the reaction of glutathione with specific genotoxic electrophiles. This compound is essential for advanced analytical research, providing an internal standard for precise quantification in mass spectrometry. It is primarily required by researchers and quality control laboratories in the pharmaceutical, toxicology, and environmental monitoring sectors for studying DNA damage mechanisms and conducting high-sensitivity bioanalytical assays.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of the corresponding non-labeled DNA adduct biomarker in complex biological matrices.
• Biomarker Research: Facilitates studies on the formation and repair of specific DNA adducts, aiding in understanding chemical carcinogenesis and genotoxicity pathways.
• Metabolic Profiling: Employed in advanced metabolomics and pharmacokinetic studies to trace the metabolic fate of compounds that form guanyl-ethyl adducts.
• Toxicology & Safety Assessment: Critical for in vitro and in vivo toxicology studies to assess exposure to specific alkylating agents and related toxins.
• Method Development & Validation: Serves as a key reference material for developing and validating highly sensitive and specific analytical methods in regulatory science.
• Pharmaceutical Impurity Profiling: Supports impurity characterization and safety evaluation of pharmaceutical compounds prone to forming reactive intermediates.

Basic Information

Product Name	S-[2-(N7-Guanyl)Ethyl-D4]GSH
CAS No.	220317-14-6
Molecular Formula	C17H26D4N7O8S
Molecular Weight	504.55 g/mol (for deuterated form)
Synonyms	S-[2-(N7-Guanyl)ethyl-d4]glutathione; Deuterated S-(2-(N7-guanyl)ethyl)glutathione; GSH-d4 adduct; N7-(2-Glutathion-S-yl-ethyl-d4)guanine; 1,1,2,2-D4-S-(2-(N7-guanyl)ethyl)glutathione; S-(2-(7-Guaninyl)ethyl-d4)glutathione; N7-(2-((2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanamido)ethyl-d4)guanine
EINECS	Contact for details

Quality Control

Our S-[2-(N7-Guanyl)Ethyl-D4]GSH is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and MS/NMR for structural confirmation and isotopic enrichment verification, to ensure it meets the high standards required for research and analytical applications. Certificates of Analysis (COA) detailing purity, isotopic purity, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D4)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.