Description

1-Pyrrolidinecarboxaldehyde, 2,5-Bis(Hydroxymethyl)-, (2R,5S)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional structure, featuring both an aldehyde and two hydroxymethyl groups on a pyrrolidine scaffold, enabling its use as a versatile precursor for complex molecule construction. This compound is critically needed by research and development teams in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis, medicinal chemistry, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly those targeting neurological and metabolic disorders.
• Asymmetric Catalysis Ligand Precursor: Used to develop novel chiral ligands and organocatalysts for enantioselective transformations.
• Peptidomimetic & Proline Derivative Synthesis: Serves as a foundational scaffold for creating peptidomimetics and modified amino acids, expanding chemical space in drug discovery.
• Fine Chemical & Specialty Chemical Production: Employed in the multi-step synthesis of high-value, optically pure fine chemicals and agrochemicals.
• Academic & Industrial Research: A valuable tool for methodological development in organic chemistry and exploring new reaction pathways.
• Bioconjugation & Linker Chemistry: The reactive aldehyde and hydroxyl groups facilitate its use in creating bioconjugates and chemical linkers for various applications.

Basic Information

Product Name	1-Pyrrolidinecarboxaldehyde, 2,5-Bis(Hydroxymethyl)-, (2R,5S)-Rel- (9Ci)
CAS No.	220264-29-9
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	(2R,5S)-2,5-Bis(hydroxymethyl)pyrrolidine-1-carbaldehyde; rel-(2R,5S)-2,5-Bis(hydroxymethyl)-1-pyrrolidinecarboxaldehyde; (2R,5S)-2,5-Di(hydroxymethyl)pyrrolidine-1-carboxaldehyde; 2,5-Bis(hydroxymethyl)-1-pyrrolidinecarboxaldehyde (rel-(2R,5S)-form); (R,S)-2,5-Bis(hydroxymethyl)pyrrolidine-1-carbaldehyde; 1-Formyl-2,5-bis(hydroxymethyl)pyrrolidine (stereoisomer); Chiral pyrrolidine aldehyde derivative
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxaldehyde, 2,5-Bis(Hydroxymethyl)-, (2R,5S)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.