Description

7-Trifluoromethyl-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. Its core value lies in the trifluoromethyl group, which imparts unique physicochemical properties critical for modulating the bioactivity and metabolic stability of target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine moiety enhances lipophilicity and environmental stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes and enzyme inhibitors to study biological pathways.
• Material Science Research: Investigated as a precursor for specialty polymers and advanced organic materials with tailored electronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring fluorinated isoquinoline derivatives.

Basic Information

Product Name	7-Trifluoromethyl-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride
CAS No.	220247-87-0
Molecular Formula	C10H11ClF3N
Molecular Weight	237.65 g/mol
Synonyms	7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 7-Trifluoromethyl-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydro-7-(trifluoromethyl)isoquinoline hydrochloride; 7-Trifluoromethyl-THIQ hydrochloride; 7-CF3-THIQ·HCl; 220247-87-0; 7-Trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline monohydrochloride
EINECS	Contact for details

Quality Control

Our 7-Trifluoromethyl-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with each shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.