Description

1,2,3,4-Tetrahydro-Isoquinoline-7-Carboxylic Acid Methyl Ester Hcl is a high-purity pharmaceutical intermediate and versatile organic building block. This compound is critical for the synthesis of complex molecules, offering a key structural motif for medicinal chemistry research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting the central nervous system.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Organic Synthesis Building Block: Used in the construction of complex heterocyclic compounds and alkaloid analogs in academic and industrial laboratories.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals and advanced materials.
• Biochemical Research: May be used as a reagent or standard in biochemical assays and analytical method development.

Basic Information

Item	Details
Product Name	1,2,3,4-Tetrahydro-Isoquinoline-7-Carboxylic Acid Methyl Ester Hcl
CAS No.	220247-69-8
Molecular Formula	C12H15NO2 • HCl
Molecular Weight	241.71 g/mol (Free base: 205.25 g/mol)
Synonyms	Methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate hydrochloride; 7-(Methoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1,2,3,4-Tetrahydro-7-isoquinolinecarboxylic acid methyl ester hydrochloride; THIQ-7-COOMe•HCl; 7-Carbomethoxy-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydroisoquinoline-7-carboxylic acid methyl ester hydrochloride salt
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-Isoquinoline-7-Carboxylic Acid Methyl Ester Hcl is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.