Description

7-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonyl-substituted tetrahydroisoquinoline scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, kinase inhibitors, and other therapeutic small molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Development: Serves as a precursor in the synthesis of potential therapeutics targeting neurological disorders.
• Kinase Inhibitor Synthesis: Employed in the construction of molecules designed to modulate kinase activity for oncology and inflammatory disease applications.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring this specific sulfonamide derivative.

Basic Information

Product Name	7-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	220247-55-2
Molecular Formula	C10H13NO2S
Molecular Weight	211.28 g/mol
Synonyms	7-(Methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-(methylsulfonyl)isoquinoline; 7-Methanesulfonyl-1,2,3,4-tetrahydroisoquinoline; 7-Methylsulfonyl-1,2,3,4-tetrahydroisoquinoline; 220247-55-2; 7-(Methylsulfonyl)THIQ; 7-Mesyl-THIQ
EINECS	Contact for details

Quality Control

Our 7-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.