Description

3-(Trifluoromethoxy)Thiophenol is a high-value organosulfur and organofluorine building block characterized by its reactive thiol (-SH) group and trifluoromethoxy substituent. This compound matters for its unique ability to introduce both sulfur and fluorine functionalities into target molecules, enabling the fine-tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, where the trifluoromethoxy group can enhance blood-brain barrier penetration.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the sulfur and fluorine atoms contribute to biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science: Employed in the development of novel monomers for specialty polymers, liquid crystals, and organic electronic materials due to its distinct electronic properties.
• Chemical Biology Probe: Utilized in bioconjugation and probe design for studying protein function and cellular processes, leveraging the reactivity of the thiol group.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(Trifluoromethoxy)Thiophenol
CAS No.	220239-66-7
Molecular Formula	C7H5F3OS
Molecular Weight	194.17 g/mol
Synonyms	3-(Trifluoromethoxy)benzenethiol; α,α,α-Trifluoro-m-cresol Sulfide; 3-(Trifluoromethoxy)phenyl mercaptan; m-(Trifluoromethoxy)thiophenol; 1-Mercapto-3-(trifluoromethoxy)benzene; 3-Trifluoromethoxybenzenethiol; 3-Trifluoromethoxythiophenol; (3-Trifluoromethoxyphenyl)thiol
EINECS	Contact for details

Quality Control

Every batch of 3-(Trifluoromethoxy)Thiophenol is produced and analyzed under strict quality management protocols. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Allow the container to reach ambient temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.