Description

[Methyl-D3]Metanicotine is a deuterium-labeled analog of metanicotine, a nicotinic acetylcholine receptor agonist. This stable isotope-labeled compound is essential for use as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in research data. It is primarily utilized by analytical chemists and researchers in the pharmaceutical, agrochemical, and forensic toxicology industries for advanced mass spectrometry (LC-MS/MS, GC-MS) and metabolic studies.

Application

• Internal Standard for Quantitative Analysis: Serves as a critical reference compound in LC-MS/MS and GC-MS for the precise quantification of metanicotine and related metabolites.
• Pharmacokinetic and Metabolic Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track and quantify drug metabolites in biological matrices.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during drug development.
• Forensic and Clinical Toxicology: Enables accurate measurement of metanicotine levels in forensic analysis and clinical samples for toxicological assessments.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques that require a known quantity of an isotopically labeled analog.
• Biochemical Research: Used as a tool to study the binding and function of nicotinic acetylcholine receptors without isotopic interference.

Basic Information

Product Name	[Methyl-D3]Metanicotine
CAS No.	220088-40-4
Molecular Formula	C11H12D3N3
Molecular Weight	190.26 g/mol
Synonyms	Metanicotine-d3; 3-[(2S)-1-Methyl-2-pyrrolidinyl]pyridine-d3; (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine-d3; (S)-N-Methyl-2-(3-pyridyl)pyrrolidine-d3; Deuteronated Metanicotine; Metanicotine (methyl-d3); Stable Isotope Labeled Metanicotine; A-84543-d3
EINECS	Contact for details

Quality Control

Our [Methyl-D3]Metanicotine is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic methods, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical identity. A comprehensive Certificate of Analysis (COA) is provided, detailing purity (by HPLC), isotopic purity, and analytical results, supporting compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.