Description

3-(4-Bromophenyl)-5-(Trifluoromethyl)-1H-Pyrazole is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound is critical for research and development in life sciences, offering a unique structural motif that combines a bromoaryl group with a trifluoromethyl-substituted pyrazole core. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials. Its specific reactivity profile makes it an essential intermediate for coupling reactions and the creation of complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and anti-inflammatory agent discovery.
• Agrochemical Active Ingredient Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrazole and trifluoromethyl groups.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Cross-Coupling Reactions: The bromophenyl moiety is an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Ligand Synthesis for Catalysis: Utilized in the preparation of specialized pyrazole-based ligands for transition metal catalysis.
• Chemical Biology Probe Development: Employed in the synthesis of molecular probes for studying biological targets and pathways.

Basic Information

Product Name	3-(4-Bromophenyl)-5-(Trifluoromethyl)-1H-Pyrazole
CAS No.	219986-65-9
Molecular Formula	C10H6BrF3N2
Molecular Weight	291.07 g/mol
Synonyms	5-(Trifluoromethyl)-3-(4-bromophenyl)-1H-pyrazole; 3-(4-Bromophenyl)-5-(trifluoromethyl)pyrazole; 1H-Pyrazole, 3-(4-bromophenyl)-5-(trifluoromethyl)-; 4-Bromo-α,α,α-trifluoro-3-pyrazol-3-yltoluene; 3-(p-Bromophenyl)-5-(trifluoromethyl)pyrazole; 3-(4-Bromophenyl)-5-trifluoromethyl-1H-pyrazole
EINECS	Contact for details

Quality Control

Our 3-(4-Bromophenyl)-5-(Trifluoromethyl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.