Description

(2R,4S,5R)-2-Hydroxymethyl-5-Ethylquinuclidine is a high-purity, stereochemically defined quinuclidine derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of active pharmaceutical ingredients (APIs). It is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries where precise stereochemistry and high purity are non-negotiable for efficacy and regulatory compliance.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly those targeting neurological and cardiovascular pathways.
• Asymmetric Catalysis: Used as a precursor or ligand in the development of chiral catalysts for stereoselective chemical reactions.
• Agrochemical Research: Serves as a building block for novel pesticides and herbicides where specific stereochemistry influences biological activity.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Academic & R&D: A valuable reference standard and starting material for medicinal chemistry research and process development in laboratory settings.

Basic Information

Product Name	(2R,4S,5R)-2-Hydroxymethyl-5-Ethylquinuclidine
CAS No.	219794-81-7
Molecular Formula	C10H19NO
Molecular Weight	169.26 g/mol
Synonyms	5-Ethyl-2-(hydroxymethyl)quinuclidine; (2R,4S,5R)-5-Ethyl-2-(hydroxymethyl)quinuclidine; 2-Hydroxymethyl-5-ethylquinuclidine; Quinuclidine, 2-(hydroxymethyl)-5-ethyl-, (2R,4S,5R)-; (2R,4S,5R)-2-(Hydroxymethyl)-5-ethylquinuclidine; Ethylquinuclidinol derivative
EINECS	Contact for details

Quality Control

Every batch of (2R,4S,5R)-2-Hydroxymethyl-5-Ethylquinuclidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided to guarantee compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.