Description

1H-Indazole-1-Carboxylic Acid, 3-Chloro-6-Nitro-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific indazole core structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily sought after by pharmaceutical manufacturers, biotechnology R&D labs, and fine chemical synthesis specialists for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting kinase inhibition or other enzyme-related pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Agrochemical Synthesis: Potential intermediate in the development of advanced pesticides and herbicides due to its heterocyclic nitro-chloro structure.
• Organic Synthesis Reagent: Serves as a protected carboxylic acid derivative for peptide coupling and other complex organic transformations in fine chemical production.
• Biochemical Tool Compound: Can be utilized in biochemical assays and as a precursor for labeled compounds used in diagnostic or imaging applications.

Basic Information

Product Name	1H-Indazole-1-Carboxylic Acid, 3-Chloro-6-Nitro-, 1,1-Dimethylethyl Ester
CAS No.	219507-79-6
Molecular Formula	C₁₂H₁₂ClN₃O₄
Molecular Weight	297.70 g/mol
Synonyms	tert-Butyl 3-chloro-6-nitro-1H-indazole-1-carboxylate; 3-Chloro-6-nitro-1H-indazole-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-chloro-6-nitro-1H-indazole; Boc-3-chloro-6-nitroindazole; 3-Chloro-6-nitroindazole-1-carboxylic acid tert-butyl ester; tert-Butyl 3-chloro-6-nitroindazole-1-carboxylate; 1H-Indazole-1-carboxylic acid, 3-chloro-6-nitro-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1H-Indazole-1-Carboxylic Acid, 3-Chloro-6-Nitro-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.