Description

1-Boc-6-Amino-Indazole is a high-purity, protected indazole derivative widely used as a critical pharmaceutical intermediate. This compound is essential for the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for developing novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile indazole scaffold.
• Peptidomimetic Synthesis: Serves as a precursor for constructing complex molecules that mimic peptide structures.
• API Development: Integral in the multi-step synthesis of advanced Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds.

Basic Information

Product Name	1-Boc-6-Amino-Indazole
CAS No.	219503-81-8
Molecular Formula	C₁₂H₁₅N₃O₂
Molecular Weight	233.27 g/mol
Synonyms	1-[(tert-Butoxy)carbonyl]-1H-indazol-6-amine; tert-Butyl 6-amino-1H-indazole-1-carboxylate; 6-Amino-1H-indazole-1-carboxylic acid tert-butyl ester; 1-Boc-6-aminoindazole; 1H-Indazole-6-amine, 1-[(1,1-dimethylethoxy)carbonyl]-; Boc-6-Aminoindazole; 6-Amino-1-Boc-indazole; N-Boc-6-aminoindazole
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Amino-Indazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, NMR, and mass spectrometry, to verify identity and purity. Certificates of Analysis (COA) are available for every batch upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.