Description

tert-Butyl 6-Nitro-1H-indazole-1-carboxylate is a high-purity, protected indazole derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a versatile, reactive scaffold for constructing complex heterocyclic molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other enzyme-related pathways.
• Medicinal Chemistry Research: Used as a versatile building block for constructing indazole-based compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Development: Serves as an intermediate in the research and synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized in the development of molecular probes and labeled compounds for studying biological mechanisms.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: A valuable reagent for universities and research institutes conducting studies in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	tert-Butyl 6-Nitro-1H-indazole-1-carboxylate
CAS No.	219503-74-9
Molecular Formula	C₁₂H₁₃N₃O₄
Molecular Weight	263.25 g/mol
Synonyms	1H-Indazole-1-carboxylic acid, 6-nitro-, 1,1-dimethylethyl ester; 6-Nitro-1H-indazole-1-carboxylic acid tert-butyl ester; tert-Butyl 6-nitroindazole-1-carboxylate; Boc-6-nitroindazole; 1-Boc-6-nitro-1H-indazole; 219503-74-9; tert-Butyl 6-nitro-1H-indazole-1-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Nitro-1H-indazole-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GLP and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or an opaque secondary container until use.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.