Description

2-[(4-Chlorophenyl)Sulfonyl]-6,7-Dimethoxy-1-Methyl-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of sophisticated active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular research. Pharmaceutical manufacturers and advanced R&D laboratories need this precise chemical to develop and scale up novel therapeutic candidates, ensuring process consistency and regulatory compliance from discovery to production.

Application

This specialized intermediate serves pivotal functions in advanced chemical synthesis across several high-value industries.

• Pharmaceutical Intermediate: Primary use as a core scaffold for synthesizing novel isoquinoline-based drug candidates.
• Neurological & CNS Drug Research: Key precursor in the development of potential therapeutics targeting specific neurological pathways.
• Cardiovascular Agent Synthesis: Building block for research into compounds with potential cardiovascular activity.
• Chemical Biology & Proteomics: Used as a specialized ligand or probe in studying enzyme interactions and protein function.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling production from laboratory to pilot plant scale.
• Academic & Institutional Research: Serves as a reference standard and starting material for novel organic methodology development in university settings.

Basic Information

Item	Details
Product Name	2-[(4-Chlorophenyl)Sulfonyl]-6,7-Dimethoxy-1-Methyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	218929-97-6
Molecular Formula	C18H20ClNO4S
Molecular Weight	381.87 g/mol
Synonyms	6,7-Dimethoxy-1-methyl-2-[(4-chlorophenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline; 2-(4-Chlorobenzenesulfonyl)-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline; 1-Methyl-2-(4-chlorophenylsulfonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; CAS 218929-97-6; Tetrahydroisoquinoline sulfonamide derivative; 4-Chloro-N-(6,7-dimethoxy-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)benzenesulfonamide (tautomeric form)
EINECS	Contact for details

Quality Control

Our 2-[(4-Chlorophenyl)Sulfonyl]-6,7-Dimethoxy-1-Methyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency suitable for pharmaceutical development. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture exposure. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.