Description

6-Chloro-8-Iodo-9-(Tetrahydro-Pyran-2-Yl)-9H-Purine is a high-purity, halogenated purine derivative of significant interest in advanced organic synthesis. This compound serves as a critical synthetic intermediate, valued for its unique halogen substitution pattern which enables selective cross-coupling and nucleophilic substitution reactions. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of nucleoside analogs, kinase inhibitors, and other bioactive heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel purine-based active pharmaceutical ingredients (APIs) and prodrugs.
• Nucleoside Analog Synthesis: Used in the research and development of modified nucleosides with potential antiviral or anticancer activity.
• Kinase Inhibitor Development: Serves as a core scaffold in medicinal chemistry programs targeting protein kinases.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying purinergic signaling pathways and enzyme function.
• Agrochemical Research: Intermediate in the development of new herbicides or plant growth regulators based on purine chemistry.
• Material Science: Potential precursor for specialty polymers or ligands in catalytic systems.

Basic Information

Product Name	6-Chloro-8-Iodo-9-(Tetrahydro-Pyran-2-Yl)-9H-Purine
CAS No.	218431-10-8
Molecular Formula	C10H10ClIN4O
Molecular Weight	364.57 g/mol
Synonyms	9-(Tetrahydro-2H-pyran-2-yl)-6-chloro-8-iodo-9H-purine; 6-Chloro-8-iodo-9-(tetrahydro-2H-pyran-2-yl)-9H-purine; 6-Chloro-8-iodo-9-(tetrahydropyran-2-yl)purine; 9H-Purine, 6-chloro-8-iodo-9-(tetrahydro-2H-pyran-2-yl)-; 6-Chloro-8-iodo-9-(THP)-9H-purine; 6-Cl-8-I-9-THP-purine; CAS 218431-10-8
EINECS	Contact for details

Quality Control

Our 6-Chloro-8-Iodo-9-(Tetrahydro-Pyran-2-Yl)-9H-Purine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.