Description

5-(1,3-Dioxan-2-Yl)-1H-Indazol-3-Amine CAS NO 218301-24-7 is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole core fused with a dioxane moiety. This compound is valued for its role as a critical building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Oncology Drug Development: Used in the research and synthesis of potential anti-cancer agents targeting specific enzymatic pathways.
• CNS-Active Compound Synthesis: Employed in the development of novel compounds for neurological and psychiatric disorders.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study biological processes and protein functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	5-(1,3-Dioxan-2-Yl)-1H-Indazol-3-Amine
CAS No.	218301-24-7
Molecular Formula	C₁₁H₁₃N₃O₂
Molecular Weight	219.24 g/mol
Synonyms	3-Amino-5-(1,3-dioxan-2-yl)-1H-indazole; 5-(1,3-Dioxan-2-yl)-1H-indazol-3-amine; 1H-Indazol-3-amine, 5-(1,3-dioxan-2-yl)-; 218301-24-7; 5-(1,3-Dioxan-2-yl)indazol-3-amine; 3-Amino-5-(1,3-dioxolan-2-yl)-1H-indazole (common misnomer); 5-(Dioxan-2-yl)-1H-indazol-3-amine
EINECS	Contact for details

Quality Control

Our 5-(1,3-Dioxan-2-Yl)-1H-Indazol-3-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with every batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.