Description

(Triisopropylsiloxy)Methyl Chloride is a specialized organosilicon reagent featuring a reactive chloromethyl group protected by a bulky triisopropylsilyl (TIPS) moiety. This compound is valued for its role as a versatile building block in organic synthesis, particularly for introducing protected hydroxymethyl or formyl equivalents under controlled conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for introducing masked aldehyde or alcohol functionalities.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the TIPS-protected chloromethyl group allows for selective transformations.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent in the development of specialty silicones and functionalized polymers.
• Organic Synthesis Reagent: Employed in multi-step synthetic sequences for natural product synthesis and medicinal chemistry, enabling complex carbon chain elongations and cyclizations.
• Protecting Group Chemistry: The triisopropylsiloxy group is used to protect alcohols in situ, with the chloromethyl handle allowing for further elaboration before deprotection.
• Ligand & Catalyst Development: Useful in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	(Triisopropylsiloxy)Methyl Chloride
CAS No.	217300-17-9
Molecular Formula	C10H23ClOSi
Molecular Weight	222.83 g/mol
Synonyms	Chloromethyl Triisopropylsilyl Ether; (Chloromethoxy)triisopropylsilane; TIPS-Protected Chloromethyl Ether; Triisopropylsilyl Chloromethyl Ether; (Triisopropylsilyloxy)methyl Chloride; 1-(Chloromethoxy)triisopropylsilane; [(Triisopropylsilyl)oxy]methyl Chloride
EINECS	Contact for details

Quality Control

Our (Triisopropylsiloxy)Methyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.