Description

3-(tert-Butyldimethylsiloxy)Thiophenol is a specialized organosilicon-protected thiol reagent, a key building block in advanced organic synthesis. Its value lies in the dual functionality of the silyl-protected phenol and the reactive thiol group, which can be selectively deprotected and functionalized. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel sulfur-containing molecules, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) containing thioether or disulfide linkages, particularly in oncology and antiviral research.
• Ligand Synthesis: Used in the preparation of sophisticated ligands for catalysis, including those for asymmetric synthesis and cross-coupling reactions.
• Polymer Modification: Serves as a functional monomer or chain-transfer agent for introducing thiol groups into polymers, enabling thiol-ene "click" chemistry for creating advanced materials.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides that utilize sulfur chemistry for enhanced activity.
• Surface Functionalization: Used to create self-assembled monolayers (SAMs) on gold and other surfaces for sensor development and nanotechnology applications.
• Peptide Mimetics & Conjugation: Facilitates the synthesis of peptide analogs and the site-specific conjugation of payloads in bioconjugation and antibody-drug conjugate (ADC) research.

Basic Information

Product Name	3-(tert-Butyldimethylsiloxy)Thiophenol
CAS No.	216393-56-5
Molecular Formula	C₁₂H₂₀OSSi
Molecular Weight	240.44 g/mol
Synonyms	3-[(tert-Butyldimethylsilyl)oxy]benzenethiol; 3-Hydroxythiophenol tert-Butyldimethylsilyl Ether; 3-Mercaptophenyl tert-Butyldimethylsilyl Ether; 3-TBDMS-Oxy Thiophenol; 3-(TBDMSO)Thiophenol; 3-(tert-Butyldimethylsilyloxy)benzenethiol; 3-Tert-Butyldimethylsiloxy Thiophenol
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyldimethylsiloxy)Thiophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and hydrolysis. The container should be kept tightly sealed in a dry environment to prevent moisture absorption. Allow the container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.