Description

1Alpha, 25-Dihydroxy Vd2-D6 is a high-purity, deuterated analog of the active metabolite of Vitamin D3 (Calcitriol). This stable isotope-labeled compound is critical for ensuring accuracy and reliability in advanced analytical research and development. It serves as an essential internal standard in mass spectrometry for the precise quantification of Vitamin D metabolites in complex biological matrices. Pharmaceutical, clinical research, and analytical laboratories rely on this material for method development, validation, and high-throughput screening.

Application

• Primary use as an internal standard in LC-MS/MS and GC-MS analysis of Vitamin D and its metabolites.
• Method development and validation for clinical diagnostics and research into Vitamin D status, deficiency, and related disorders.
• Quantitative analysis in pharmacokinetic and pharmacodynamic studies during drug development.
• Biomarker research and metabolomics studies focusing on endocrine pathways and bone metabolism.
• Quality control and assurance in the manufacturing of pharmaceutical Vitamin D analogs.
• Use in stable isotope dilution assays to achieve the highest level of analytical precision and accuracy.

Basic Information

Product Name	1Alpha, 25-Dihydroxy Vd2-D6
CAS No.	216244-04-1
Molecular Formula	C₂₇H₄₀D₆O₃
Molecular Weight	424.68 g/mol
Synonyms	1α,25-Dihydroxyvitamin D2-d6; Calcitriol-d6 (Vitamin D2 analog); (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol-d6; 1α,25-Dihydroxyergocalciferol-d6; 1,25-Dihydroxy Vitamin D2-d6; 1,25(OH)2D2-d6; ERCALCITRIOL-D6; Stable Isotope Labeled Vitamin D Metabolite
EINECS	Contact for details

Quality Control

Every batch of 1Alpha, 25-Dihydroxy Vd2-D6 is manufactured and tested under strict quality management systems to ensure the highest isotopic and chemical purity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards for stable isotope-labeled compounds. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.