Description

tert-Butyl 5-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a protected heterocyclic amine derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity building blocks for drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel therapeutic agents, particularly those targeting the central nervous system.
• Organic Synthesis Scaffold: Used in the construction of complex isoquinoline and tetrahydroisoquinoline derivatives for medicinal chemistry research.
• Agrochemical Research: Intermediate in the development of new pesticides and herbicides with specific biological activity.
• Chemical Biology Probe Development: Serves as a precursor for creating molecular probes to study enzyme function and biological pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target molecules in fine chemical manufacturing.

Basic Information

Product Name	tert-Butyl 5-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	216064-48-1
Molecular Formula	C₁₄H₁₉NO₃
Molecular Weight	249.31 g/mol
Synonyms	5-Hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester; 5-Hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 5-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; Boc-5-OH-THIQ; 5-Hydroxy-THIQ-Boc; BOC-5-Hydroxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Hydroxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), identity confirmation, and impurity profile is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.