Description

5,5'-Difluoro-3,3'-Methanediyl-Bis-Indole is a specialized fluorinated bis-indole derivative, a key building block in advanced organic synthesis. Its molecular architecture, featuring a methane bridge and strategically placed fluorine atoms, makes it a high-value intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold for the synthesis of novel drug candidates, particularly in oncology and CNS research, where the fluorine atoms can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging its structural rigidity for target specificity.
• Organic Light-Emitting Diode (OLED) Materials: Acts as a precursor for electron-transporting or host materials in OLED devices, where the fluorinated indole units contribute to charge carrier mobility.
• Ligand and Catalyst Development: Employed in the design of novel chelating ligands for transition metal catalysis, useful in asymmetric synthesis and cross-coupling reactions.
• Fluorescent Probe and Dye Chemistry: The bis-indole core is a potential starting point for synthesizing fluorophores and molecular sensors for biochemical and diagnostic applications.
• Polymer and Advanced Material Science: Incorporated into polymer backbones or as a functional monomer to create high-performance materials with specific optical or electronic characteristics.

Basic Information

Product Name	5,5'-Difluoro-3,3'-Methanediyl-Bis-Indole
CAS No.	215997-93-6
Molecular Formula	C₁₇H₁₀F₂N₂
Molecular Weight	280.27 g/mol
Synonyms	3,3'-(Methylenedi-1,3-phenylene)bis(5-fluoro-1H-indole); 5,5'-Difluoro-3,3'-methylenediindole; 5,5'-Difluoro-3,3'-methylenebis(1H-indole); 3,3'-Methylenebis(5-fluoro-1H-indole); Bis(5-fluoro-3-indolyl)methane; 215997-93-6; DFMBI
EINECS	Contact for details

Quality Control

Every batch of 5,5'-Difluoro-3,3'-Methanediyl-Bis-Indole is manufactured under a strict quality management system. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.