Description

Phosphine Oxide, [(2Z)-2-[(3S,5S)-3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Methylenecyclohexylidene]Ethyl]Diphenyl- is a sophisticated, high-purity organophosphorus compound featuring a complex, functionalized cyclohexylidene core protected by tert-butyldimethylsilyl (TBDMS) groups. This compound matters as a critical advanced synthetic intermediate and ligand precursor, enabling precise chemical transformations in complex molecule assembly. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, agrochemicals, and specialty materials, where its unique sterically hindered structure facilitates challenging synthetic steps.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, particularly in oncology and antiviral research.
• Catalyst Ligand Precursor: Serves as a precursor for chiral or sterically demanding phosphine ligands used in asymmetric catalysis (e.g., cross-coupling, hydrogenation).
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides requiring specific stereochemistry.
• Material Science Research: Employed in the synthesis of functional organic molecules for optoelectronic materials or advanced polymers.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable production of high-value fine chemicals.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic synthesis and organometallic chemistry.

Basic Information

Product Name	Phosphine Oxide, [(2Z)-2-[(3S,5S)-3,5-Bis[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-2-Methylenecyclohexylidene]Ethyl]Diphenyl-
CAS No.	215929-37-6
Molecular Formula	C₃₇H₅₉O₃PSi₂
Molecular Weight	639.02 g/mol
Synonyms	Diphenyl[(2Z)-2-[(3S,5S)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethyl]phosphine oxide; (Z)-[2-((3S,5S)-3,5-Bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethyl]diphenylphosphine oxide; TBDMS-protected phosphine oxide cyclohexylidene derivative; Sterically hindered phosphine oxide intermediate; Chiral phosphine oxide silyl ether; CAS 215929-37-6
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and controlled under a strict quality management system. We guarantee identity, purity, and stereochemical integrity through a comprehensive battery of analytical techniques including NMR (¹H, ¹³C, ³¹P), HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.