Description

6,8-Difluoro-7-Hydroxy-4-Methylcoumarin is a fluorinated derivative of the coumarin scaffold, a privileged structure in medicinal chemistry and material science. This compound matters for its role as a versatile synthetic intermediate and a key building block for developing advanced fluorescent probes and biologically active molecules. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery, sensor development, and organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting enzymes where the coumarin core is active.
• Fluorescent Probe Synthesis: Used to develop sensitive and selective fluorescent sensors and markers for bioimaging and diagnostic assays, leveraging its fluorinated structure for enhanced photophysical properties.
• Agrochemical Research: Acts as a building block for creating new active ingredients in crop protection products, such as herbicides and fungicides.
• Organic Electronic Materials: Investigated for use in the development of organic light-emitting diodes (OLEDs) and other optoelectronic devices due to its potential charge-transport and emissive characteristics.
• Biochemical Tool Development: Employed in creating enzyme inhibitors and activity-based probes for studying biological pathways in research laboratories.
• Dye and Pigment Intermediate: Functions as a specialized intermediate in the synthesis of high-performance dyes and functional pigments.

Basic Information

Product Name	6,8-Difluoro-7-Hydroxy-4-Methylcoumarin
CAS No.	215868-23-8
Molecular Formula	C10H6F2O3
Molecular Weight	212.15 g/mol
Synonyms	7-Hydroxy-6,8-difluoro-4-methylcoumarin; 4-Methyl-6,8-difluoro-7-hydroxycoumarin; 6,8-Difluoro-7-hydroxy-4-methyl-2H-chromen-2-one; 6,8-Difluoro-4-methylumbelliferone; 6,8-Difluoro-4-methyl-7-hydroxycoumarin; DFMHC
EINECS	Contact for details

Quality Control

Our 6,8-Difluoro-7-Hydroxy-4-Methylcoumarin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.