Description

Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Hydroxy-, (1R,2R,4S,5S,6S)-Rel- (9Ci) is a high-purity, stereochemically defined bicyclic amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a sophisticated chiral building block, enabling the synthesis of complex molecules with precise three-dimensional architecture. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for creating novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder research.
• Peptidomimetics Design: Used to construct conformationally constrained peptide analogs, enhancing metabolic stability and receptor selectivity.
• Ligand Synthesis for Catalysis: Employed in the preparation of chiral ligands for asymmetric synthesis, facilitating the production of enantiomerically pure compounds.
• Chemical Biology Probes: Acts as a scaffold for developing molecular probes to study enzyme mechanisms and protein-protein interactions.
• Advanced Material Precursor: Potential use in synthesizing specialty polymers and dendrimers with unique structural properties.

Basic Information

Item	Details
Product Name	Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Hydroxy-, (1R,2R,4S,5S,6S)-Rel- (9Ci)
CAS No.	215867-42-8
Molecular Formula	C9H11NO6
Molecular Weight	229.19 g/mol
Synonyms	(1R,2R,4S,5S,6S)-2-Amino-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid; rel-(1R,2R,4S,5S,6S)-2-Amino-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid; 2-Amino-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid (stereoisomer); Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-4-hydroxy-, (1R,2R,4S,5S,6S)-rel-; Constrained glutamic acid analog; Bicyclic amino acid derivative
EINECS	Contact for details

Quality Control

Every batch of our Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Hydroxy-, (1R,2R,4S,5S,6S)-Rel- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, meeting the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) including results for chiral purity, assay, and related substances is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.