Description

Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Methylene- is a high-purity, multifunctional bicyclic amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated chiral building block, offering a rigid, three-dimensional scaffold that is critical for modulating the physicochemical properties and biological activity of target molecules. Pharmaceutical and agrochemical research and development teams need it for creating novel active ingredients, particularly in the design of peptidomimetics, enzyme inhibitors, and other complex bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, including protease inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the design and synthesis of advanced, high-performance pesticides and herbicides with specific stereochemical requirements.
• Peptidomimetics & Constrained Peptide Design: Its rigid bicyclo[3.1.0]hexane core is valuable for constructing conformationally restricted peptide analogs to enhance stability and potency.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Potential monomer for the synthesis of novel polymers with unique thermal and mechanical properties.
• Bioconjugation & Probe Chemistry: The amino and carboxylic acid functionalities allow for site-specific conjugation in biopharmaceuticals or diagnostic probes.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Methylene-
CAS No.	215867-32-6
Molecular Formula	C9H11NO4
Molecular Weight	197.19 g/mol
Synonyms	2-Amino-4-methylenebicyclo[3.1.0]hexane-2,6-dicarboxylic acid; 4-Methylene-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1R,5S,6r)-2-Amino-4-methylenebicyclo[3.1.0]hexane-2,6-dicarboxylic acid (for specific stereoisomer); 2-Azabicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative; Bicyclo[3.1.0]hexane amino diacid; Constrained glutamic acid analog; Aminomethylenebicyclohexanedicarboxylic acid
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Methylene- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral analysis, to ensure high chemical and isomeric purity suitable for sensitive R&D and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when necessary.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.