Description

Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Fluoro-, (1R,2S,4R,5R,6R)-Rel- (9Ci) is a high-purity, stereochemically defined bicyclic amino acid derivative, serving as a critical advanced pharmaceutical intermediate and chiral building block for complex organic synthesis. Its unique constrained structure and specific stereochemistry make it invaluable for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily sought by pharmaceutical R&D and fine chemical synthesis teams developing novel therapeutics, including protease inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Protease Inhibitor Synthesis: Used as a core scaffold or side-chain component in the design and synthesis of potent protease inhibitors.
• Peptidomimetics Development: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and receptor selectivity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new chemical space and optimize drug candidate profiles.
• Asymmetric Synthesis: Serves as a sophisticated chiral pool reagent or template for constructing complex, enantiomerically pure molecules.
• Bioconjugation & Labeling: The carboxylic acid and amino functional groups allow for site-specific conjugation to carriers, probes, or other biomolecules.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Fluoro-, (1R,2S,4R,5R,6R)-Rel- (9Ci)
CAS No.	215867-23-5
Molecular Formula	C9H10FNO4
Molecular Weight	215.18 g/mol
Synonyms	(1R,2S,4R,5R,6R)-2-Amino-4-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; rel-(1R,2S,4R,5R,6R)-2-Amino-4-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; 2-Amino-4-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (rel-(1R,2S,4R,5R,6R)-isomer); Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-4-fluoro-, (1R,2S,4R,5R,6R)-rel-; 215867-23-5; 4-Fluoro-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles to ensure it meets the exacting standards required for pharmaceutical research. Our quality commitment aligns with cGMP principles where applicable, and specifications can be tailored to support your regulatory filings and process development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.