Description

Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Hydroxy-, (1R,2R,4R,5S,6S)-Rel- (9Ci) is a high-purity, stereochemically defined bicyclic amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block for the synthesis of complex molecules, enabling precise control over three-dimensional structure. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery of novel therapeutics, particularly in areas requiring rigid, conformationally restricted scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other bioactive molecules.
• Peptidomimetics Research: Used to construct conformationally constrained peptide analogs to enhance metabolic stability and receptor selectivity.
• Medicinal Chemistry: Serves as a versatile scaffold in structure-activity relationship (SAR) studies and lead optimization programs.
• Chemical Biology: Employed in the development of molecular probes and tools to study biological pathways and protein function.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in catalytic asymmetric reactions to introduce multiple stereocenters.
• Advanced Material Science: Potential monomer for creating novel polymers with specific chiral and structural properties.

Basic Information

Item	Details
Product Name	Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Hydroxy-, (1R,2R,4R,5S,6S)-Rel- (9Ci)
CAS No.	215867-18-8
Molecular Formula	C9H11NO6
Molecular Weight	229.19 g/mol
Synonyms	(1R,2R,4R,5S,6S)-2-Amino-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid; rel-(1R,2R,4R,5S,6S)-2-Amino-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid; 2-Amino-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid (stereoisomer); Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-4-hydroxy-, (1R,2R,4R,5S,6S)-rel-; CAS 215867-18-8
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-2,6-Dicarboxylic Acid, 2-Amino-4-Hydroxy-, (1R,2R,4R,5S,6S)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and chiral analysis to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.