Description

6-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethylated tetrahydroisoquinoline core. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, oncology therapeutics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in CNS and oncology drug discovery.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Fluorinated Compound Synthesis: Serves as a valuable precursor for introducing the trifluoromethyl group into complex molecular architectures, a common strategy in modern drug design.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the scale-up and cGMP production of clinical trial materials and commercial APIs.
• Agrochemical Research: Potential application as an intermediate in the development of novel fluorinated agrochemicals and pesticides.
• Academic & Institutional Research: Utilized in university and government labs for fundamental organic synthesis and pharmacological studies.

Basic Information

Product Name	6-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	215798-14-4
Molecular Formula	C10H10F3N·HCl
Molecular Weight	237.65 g/mol
Synonyms	6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline HCl; 6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; 6-Trifluoromethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1,2,3,4-Tetrahydro-6-(trifluoromethyl)isoquinoline hydrochloride; 6-(Trifluoromethyl)-3,4-dihydro-1H-isoquinoline hydrochloride; 6-Trifluoromethyl-THIQ HCl; 6-CF3-Tetrahydroisoquinoline HCl
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP principles for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.