Description

5-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethylated tetrahydroisoquinoline scaffold. This compound is valued for its role in medicinal chemistry, particularly in the synthesis of novel bioactive molecules where the introduction of fluorine atoms can significantly alter pharmacokinetic properties. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, enzyme inhibitors, and other therapeutic candidates. Our supply is characterized by stringent quality control to ensure batch-to-batch consistency for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the trifluoromethyl group on potency, metabolic stability, and lipophilicity.
• Chemical Biology Probes: Serves as a precursor for developing labeled compounds or probes to study biological targets and pathways.
• Agrochemical Research: Utilized in the discovery of new active ingredients for crop protection, leveraging the bioactivity of the isoquinoline core.
• Academic Synthesis: Employed in university and institutional labs for methodological development and the study of fluorinated heterocycles.
• Scale-up and Process Chemistry: Supplied in development and commercial quantities for non-GMP and GMP synthesis routes.

Basic Information

Product Name	5-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	215788-34-4
Molecular Formula	C10H11ClF3N
Molecular Weight	237.65 g/mol
Synonyms	5-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline HCl; 5-(Trifluoromethyl)-3,4-dihydro-1H-isoquinoline hydrochloride; 1,2,3,4-Tetrahydro-5-(trifluoromethyl)isoquinoline hydrochloride; 5-Trifluoromethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 215788-34-4; 5-CF3-THIQ HCl; 5-Trifluoromethyl-THIQ HCl
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or production specifications. Our quality commitment supports applications from early-stage research through to cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.