Description

Phenyl-D5-Boronic Acid CAS NO 215527-70-1 is a deuterated derivative of phenylboronic acid, where five hydrogen atoms on the phenyl ring are replaced with deuterium. This isotopic labeling is critical for applications requiring enhanced metabolic stability, reduced background noise in spectroscopic analysis, and as a non-radioactive tracer. It is an essential building block and reagent for researchers and manufacturers in advanced pharmaceutical development and analytical chemistry.

Application

• Pharmaceutical Research & Development: Key intermediate in the synthesis of deuterated drug candidates for improved pharmacokinetic profiles (Deuterated Active Pharmaceutical Ingredients - D-APIs).
• Suzuki-Miyaura Cross-Coupling Reactions: Deuterated aryl source for creating carbon-deuterium bonds in complex organic molecules and labeled materials.
• Analytical Chemistry & Mass Spectrometry: Used as an internal standard for the accurate quantification of phenylboronic acid and related compounds via LC-MS/MS.
• Metabolism Studies: Tracer compound in drug metabolism and pharmacokinetics (DMPK) research to track metabolic pathways.
• Material Science: Precursor for synthesizing deuterated polymers or organic electronic materials for specialized research.
• NMR Spectroscopy: Tool for mechanistic studies and structural analysis due to its distinct NMR signature compared to the protonated analogue.

Basic Information

Product Name	Phenyl-D5-Boronic Acid
CAS No.	215527-70-1
Molecular Formula	C6D5B(OH)2
Molecular Weight	127.97 g/mol
Synonyms	(Pentadeuterophenyl)boronic acid; Benzene-d5-boronic acid; Phenyl-d5-boronic acid; Deutero-phenylboronic acid; D5-Phenylboronic Acid; Boronic acid, B-(pentadeuterophenyl)-; (2H5)Benzeneboronic acid
EINECS	Contact for details

Quality Control

Our Phenyl-D5-Boronic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹¹B, ¹³C) for structural confirmation and deuterium incorporation, HPLC for chemical purity, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Deuterium Incorporation (D%)	≥ 98 atom % D
Purity (HPLC)	≥ 97%
Water Content (Karl Fischer)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.