Description

Fmoc-4-(3-Carboxymethyl-2-Keto-1-Benzimidazolyl)-Piperidine is a specialized, high-purity building block designed for advanced organic synthesis and pharmaceutical research. This compound is critical for the efficient construction of complex molecules, particularly in solid-phase peptide synthesis (SPPS) and the development of novel drug candidates. It is an essential reagent for medicinal chemists and researchers in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for the synthesis of peptidomimetics and other bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the sequential assembly of peptides on resin.
• Peptidomimetic Drug Discovery: Used to incorporate the unique benzimidazolone-piperidine scaffold into novel drug-like molecules to modulate biological activity.
• Combinatorial Chemistry: Serves as a versatile building block in the generation of diverse chemical libraries for high-throughput screening.
• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Bioconjugation and Probe Development: The Fmoc-protected carboxylic acid group allows for site-specific conjugation to biomolecules or fluorescent tags.
• Academic and Contract Research: Essential for research institutions and CROs (Contract Research Organizations) focused on organic methodology and medicinal chemistry projects.

Basic Information

Product Name	Fmoc-4-(3-Carboxymethyl-2-Keto-1-Benzimidazolyl)-Piperidine
CAS No.	215190-29-7
Molecular Formula	C26H27N3O5
Molecular Weight	461.51 g/mol
Synonyms	Fmoc-4-(3-Carboxymethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(3-carboxymethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine; Fmoc-4-(3-Carboxymethyl-2-oxo-1-benzimidazolyl)piperidine; N-α-Fmoc-4-(3-carboxymethyl-2-oxo-1-benzimidazolyl)piperidine; Fmoc-Pip(Bzi-COOH)-OH; Fmoc-4-(3-Carboxymethyl-2-oxobenzimidazol-1-yl)piperidine
EINECS	Contact for details

Quality Control

Our Fmoc-4-(3-Carboxymethyl-2-Keto-1-Benzimidazolyl)-Piperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.