Description

5-Bromo-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern organic synthesis. Its core value lies in serving as a versatile and protected building block for constructing complex nitrogen-containing heterocycles, which are prevalent in active pharmaceutical ingredients. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel isoquinoline and tetrahydroisoquinoline-based drug candidates targeting central nervous system disorders, oncology, and cardiovascular diseases.
• Organic Synthesis Building Block: Used for introducing the brominated dihydroisoquinoline scaffold into more complex molecular architectures via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization to explore new chemical space for therapeutic agents.
• Agrochemical Development: Serves as an intermediate in the research and synthesis of new crop protection agents and pesticides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	5-Bromo-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	215184-78-4
Molecular Formula	C₁₄H₁₆BrNO₂
Molecular Weight	310.19 g/mol
Synonyms	tert-Butyl 5-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylate; 5-Bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 5-Bromo-3,4-dihydro-2H-isoquinoline-1-carboxylic acid tert-butyl ester; 5-Bromotetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 5-Bromo-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 1,1-dimethylethyl ester; BOC-5-Bromo-THIQ; 5-Bromo-THIQ-OtBu
EINECS	Contact for details

Quality Control

Our 5-Bromo-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.