Description

2-((tert-Butoxycarbonyl)Amino)-3-Oxooctahydroindolizine-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex indolizine scaffold protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for the synthesis of complex molecules, offering a versatile chiral building block for constructing pharmacologically active structures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological and metabolic disorders.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and constrained peptides due to its rigid, bicyclic indolizine structure.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for clients.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2-((tert-Butoxycarbonyl)Amino)-3-Oxooctahydroindolizine-5-Carboxylic Acid
CAS No.	215182-89-1
Molecular Formula	C14H22N2O5
Molecular Weight	298.34 g/mol
Synonyms	Boc-Protected 3-Oxoindolizine-5-carboxylic Acid Derivative; 5-Carboxy-2-((tert-butoxycarbonyl)amino)octahydroindolizin-3-one; 2-[(tert-Butoxycarbonyl)amino]-3-oxo-1,2,3,5,6,7,8,8a-octahydroindolizine-5-carboxylic Acid; (5S,8aR)-2-[(tert-Butoxycarbonyl)amino]-3-oxooctahydroindolizine-5-carboxylic Acid (stereoisomer); 2-(Boc-amino)-3-oxooctahydroindolizine-5-carboxylic Acid; Indolizine-5-carboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]octahydro-3-oxo-; Advanced Indolizine Intermediate; Boc-Amino Oxoindolizine Carboxylic Acid.
EINECS	Contact for details

Quality Control

Our 2-((tert-Butoxycarbonyl)Amino)-3-Oxooctahydroindolizine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical R&D and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee (by chiral HPLC)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.