Description

5S,9Alpha, 11Alpha-Trihydroxy-(8Beta)-Prosta-6E,14Z-Dien-1-Oic-17,17,18,18-D4 Acid is a high-purity, deuterium-labeled analog of a key prostaglandin metabolite. This compound is of significant value as a critical stable isotope-labeled internal standard for mass spectrometry-based bioanalytical assays, ensuring precise quantification. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and diagnostic kit manufacturers engaged in lipidomics, drug metabolism, and pharmacokinetic studies.

Application

• Quantitative Bioanalysis: Serves as an essential internal standard for the accurate LC-MS/MS quantification of related prostaglandins and eicosanoids in biological matrices (plasma, serum, urine, tissue homogenates).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in preclinical and clinical studies to track the metabolism and clearance of drug candidates affecting the arachidonic acid pathway.
• Biomarker Research: Enables precise measurement of inflammatory and oxidative stress biomarkers in research focused on cardiovascular disease, oncology, and metabolic disorders.
• Diagnostic Assay Development: Incorporated into commercial immunoassay or mass spectrometry kits as a calibrator or reference material to ensure assay reliability and standardization.
• Lipidomics and Metabolomics: A key reference compound in high-throughput profiling studies aiming to map lipid mediator pathways and their dysregulation in disease states.
• Quality Control for Pharmaceutical Manufacturing: Used in analytical method development and validation to monitor process-related impurities or degradation products in prostaglandin-based APIs.

Basic Information

Product Name	5S,9Alpha, 11Alpha-Trihydroxy-(8Beta)-Prosta-6E,14Z-Dien-1-Oic-17,17,18,18-D4 Acid
CAS No.	214977-79-4
Molecular Formula	C20H28D4O5
Molecular Weight	~356.49 g/mol
Synonyms	15-Deoxy-δ12,14-PGJ2-d4; 15-Deoxy-δ-12,14-prostaglandin J2-d4; 15d-PGJ2-d4; 5S,9α,11α-Trihydroxy-(8β)-prosta-6E,14Z-dien-1-oic-17,17,18,18-d4 Acid; 15-Deoxy-δ12,14-Prostaglandin J2-d4; Deuterated 15-deoxy-δ12,14-PGJ2; 15d-PGJ2 Deuterated Internal Standard
EINECS	Contact for details

Quality Control

Every batch of our deuterated prostaglandin standards is produced and analyzed under strict quality control protocols to ensure isotopic purity and chemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing results from NMR, HPLC, and mass spectrometry. Our quality system is designed to meet the exacting requirements of GMP/GLP-compliant laboratories, supporting traceable and reproducible research outcomes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 90%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.