Description

Benzene, 1-Fluoro-4-(Methylenecyclopropyl)- (9Ci) is a specialized fluorinated aromatic building block featuring a reactive methylenecyclopropyl substituent. This compound matters for its unique structural motif, which enables the synthesis of complex molecules with constrained geometry and potential biological activity. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for use in medicinal chemistry, drug discovery, and the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the methylenecyclopropyl pharmacophore.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the fluorine atom and cyclopropyl group enhance stability and bioactivity.
• Material Science Research: Serves as a precursor for novel fluorinated polymers or liquid crystals with specific electronic or optical properties.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, or other palladium-catalyzed cross-coupling reactions to build complex aromatic systems.
• Medicinal Chemistry Probe: Utilized in structure-activity relationship (SAR) studies to explore the impact of fluorinated cyclopropyl groups on potency and metabolic stability.
• Fine Chemical Production: Employed in the custom synthesis of high-value, low-volume specialty chemicals for advanced research applications.

Basic Information

Product Name	Benzene, 1-Fluoro-4-(Methylenecyclopropyl)- (9Ci)
CAS No.	214958-02-8
Molecular Formula	C10H9F
Molecular Weight	148.18 g/mol
Synonyms	1-Fluoro-4-(methylenecyclopropyl)benzene; 4-Fluoro-α-methylenecyclopropanebenzene; (4-Fluorophenyl)methylenecyclopropane; p-Fluoro-α-methylenecyclopropylbenzene; 1-Fluoro-4-(methylenecyclopropyl)benzene (9CI); Benzene, 1-fluoro-4-(methylenecyclopropyl)-; 214958-02-8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for each parameter are available upon request, supporting your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.