Description

5-Fluoro-2-Thiophenemethamine is a high-value fluorinated heterocyclic building block, specifically a functionalized thiophene derivative. This compound is critical for introducing both fluorine and an amine handle into complex molecular architectures, enabling precise modulation of physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances bioavailability and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of conductive polymers, organic semiconductors, and specialty coatings.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: An essential building block in academic and industrial R&D focused on exploring structure-activity relationships (SAR) in fluorinated compounds.
• Diagnostic Agent Development: Potential use in the synthesis of radiolabeled probes or contrast agents for imaging applications.

Basic Information

Product Name	5-Fluoro-2-Thiophenemethamine
CAS No.	214759-36-1
Molecular Formula	C5H6FNS
Molecular Weight	131.17 g/mol
Synonyms	(5-Fluorothiophen-2-yl)methanamine; 2-(Aminomethyl)-5-fluorothiophene; 5-Fluoro-2-thiophenemethylamine; 5-Fluorothiophene-2-methanamine; 5-Fluoro-2-thienylmethanamine; 2-Aminomethyl-5-fluorothiophene; 5-Fluoro-2-thienylmethylamine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Thiophenemethamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This amine derivative is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.