Description

Thiophene-3-Ol, 4-Aminotetrahydro-, 1,1-Dioxide, (3S,4R)- (9Ci) is a high-purity, stereochemically defined sulfone derivative of aminotetrahydrothiophene, serving as a critical chiral building block and advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex molecules with precise stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs) with targeted efficacy. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new Active Pharmaceutical Ingredients (APIs), especially in neurological and metabolic disorder treatments.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom synthesis of proprietary compounds for clients in the life sciences sector.

Basic Information

Product Name	Thiophene-3-Ol, 4-Aminotetrahydro-, 1,1-Dioxide, (3S,4R)- (9Ci)
CAS No.	214629-32-0
Molecular Formula	C4H9NO3S
Molecular Weight	151.18 g/mol
Synonyms	(3S,4R)-4-Aminotetrahydrothiophene-3-ol 1,1-Dioxide; (3S,4R)-3-Hydroxy-4-aminotetrahydrothiophene 1,1-Dioxide; 4-Amino-3-hydroxy-tetrahydrothiophene 1,1-dioxide (3S,4R)-; cis-4-Amino-3-hydroxytetrahydrothiophene 1,1-dioxide; Tetrahydro-4-amino-3-thiophenol 1,1-dioxide (3S,4R)-; Aminohydroxytetrahydrothiophene dioxide; Chiral thiophene sulfone intermediate
EINECS	Contact for details

Quality Control

Our Thiophene-3-Ol, 4-Aminotetrahydro-, 1,1-Dioxide, (3S,4R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.