Description

1H-Indole-3-Carboxamide, n-[(1R,2S)-2-[[(2R)-2-[Methyl[2-(4-Methylphenyl)Acetyl]Amino]-3-(2-Naphthalenyl)-1-Oxopropyl]Amino]Cyclohexyl]- is a sophisticated, high-purity chiral organic compound designed for advanced research and development. This molecule is of significant interest as a key intermediate or building block in the synthesis of novel pharmaceutical candidates, particularly those targeting complex biological pathways. It is essential for medicinal chemistry research and process development within the pharmaceutical and biotechnology industries, where precise molecular architecture is critical for biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of potential active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or oncology targets.
• Medicinal Chemistry Research: Used in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization due to its complex indole and naphthalene-based structure.
• Process Chemistry Development: Employed in scaling up synthetic routes for novel therapeutic compounds, requiring high chemical purity and stereochemical integrity.
• Biochemical Research: May be utilized as a tool compound or ligand in biochemical assays to study protein interactions and enzyme inhibition.
• Custom Synthesis: Acts as a starting material for the custom synthesis of more complex, proprietary molecules for client-specific R&D projects.

Basic Information

Product Name	1H-Indole-3-Carboxamide, n-[(1R,2S)-2-[[(2R)-2-[Methyl[2-(4-Methylphenyl)Acetyl]Amino]-3-(2-Naphthalenyl)-1-Oxopropyl]Amino]Cyclohexyl]-
CAS No.	214487-45-3
Molecular Formula	C38H41N3O3
Molecular Weight	587.75 g/mol
Synonyms	N-[(1R,2S)-2-[[(2R)-2-[Methyl[2-(4-Methylphenyl)acetyl]amino]-3-(naphthalen-2-yl)-1-oxopropyl]amino]cyclohexyl]-1H-indole-3-carboxamide; (2R)-N-[(1R,2S)-2-[[(2R)-2-[Methyl[2-(4-methylphenyl)acetyl]amino]-3-(naphthalen-2-yl)propanoyl]amino]cyclohexyl]-1H-indole-3-carboxamide; UNII-9P3H8B2B4F; 9P3H8B2B4F; Aprepitant Intermediate Derivative; CAS 214487-45-3.
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure the highest standards of chemical purity and stereochemical consistency. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Our quality system is designed to support cGMP-compliant applications in pharmaceutical development, with documentation available for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storing under an inert gas such as argon or nitrogen in a sealed container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.