Description

1-Chloro-6-Fluoroisoquinoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is specifically engineered to serve as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the fluorinated isoquinoline scaffold.
• Material Science Precursor: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a fluorescent tag or probe due to its inherent photophysical properties.
• Cross-Coupling Reactions: The chloro and fluoro substituents make it an excellent substrate for selective palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Library Synthesis: Employed in parallel and combinatorial chemistry for the rapid generation of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	1-Chloro-6-Fluoroisoquinoline
CAS No.	214045-86-0
Molecular Formula	C9H5ClFN
Molecular Weight	181.59 g/mol
Synonyms	6-Fluoro-1-chloroisoquinoline; 1-Chloro-6-fluoro-isoquinoline; Isoquinoline, 1-chloro-6-fluoro-; 214045-86-0; 6-Fluoro-1-chloro-isoquinoline; 1-Chloro-6-fluoroisoquinoline; 6-Fluoro-1-chloroisoquinoline
EINECS	Contact for details

Quality Control

Our 1-Chloro-6-Fluoroisoquinoline is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.