Description

D-[2,5-13C2]Ribose is a stable isotope-labeled analog of the essential pentose sugar, D-ribose, specifically enriched with carbon-13 at the 2 and 5 positions. This precise labeling makes it an indispensable tool for advanced metabolic research and analytical method development, providing critical insights into biochemical pathways. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS).

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic pathway activity and carbon flow in biological systems.
• NMR Spectroscopy Studies: Serves as a crucial internal standard or probe for structural elucidation and dynamic studies of nucleic acids, nucleotides, and glycans.
• Mass Spectrometry (MS) Quantification: Employed as a stable isotope-labeled internal standard for the accurate and precise quantification of ribose and its derivatives in complex biological matrices.
• Pharmaceutical Research: Facilitates drug metabolism and pharmacokinetics (DMPK) studies for nucleotide-based therapeutics.
• Biochemical Pathway Investigation: Enables detailed research into the pentose phosphate pathway, nucleotide synthesis, and glycosylation processes.
• Diagnostic Assay Development: Used in the development of high-sensitivity clinical diagnostic tests for metabolic disorders.

Basic Information

Item	Detail
Product Name	D-[2,5-13C2]Ribose
CAS No.	213825-57-1
Molecular Formula	C5H10O5 (with 13C at positions 2 & 5)
Molecular Weight	152.12 (based on 13C enrichment)
Synonyms	D-Ribose-2,5-13C2; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-2,5-13C2; 2,5-13C2-D-Ribose; 13C2-Labeled D-Ribose; Isotopically Labeled Ribose; Stable Isotope-Labeled Pentose; Ribose-13C2; D-Ribose (2,5-13C2)
EINECS	Contact for details

Quality Control

Every batch of D-[2,5-13C2]Ribose is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity, critical for sensitive research applications. Our products undergo rigorous quality testing, including comprehensive spectroscopic and chromatographic analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical methods (NMR, HPLC, MS) are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Isotopic Enrichment (13C)	≥ 99 atom % (at positions 2 & 5)
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.