Description

2-Amino-6-tert-Butyl-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. Pharmaceutical R&D teams and fine chemical manufacturers need this precise chemical to develop next-generation drug candidates, leveraging its unique scaffold to impart specific biological activity and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, where its benzo[b]thiophene core can contribute to novel modes of action.
• Material Science Chemistry: Acts as a specialty monomer or additive in the research of advanced polymers and organic electronic materials due to its fused ring system.
• Academic & Contract Research: Essential for medicinal chemistry programs in universities and CROs (Contract Research Organizations) focused on heterocyclic compound libraries and structure-activity relationship (SAR) studies.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	2-Amino-6-tert-Butyl-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	213192-26-8
Molecular Formula	C₁₆H₂₃NO₂S
Molecular Weight	293.42 g/mol
Synonyms	Methyl 2-amino-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 6-tert-Butyl-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid methyl ester; 2-Amino-6-(1,1-dimethylethyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid methyl ester; 213192-26-8; Methyl 2-amino-6-(tert-butyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
EINECS	Contact for details

Quality Control

Our production of 2-Amino-6-tert-Butyl-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, and NMR for comprehensive characterization. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting cGMP-compliant manufacturing workflows for our global pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.