Description

(3S,4As,8As)-Decahydro-n-(2-Hydroxy-1,1-Dimethylethyl)-3-Isoquinolinecarboxamide is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined polycyclic structure. This compound is critical for the synthesis of novel therapeutic agents, particularly in the development of central nervous system (CNS) and antiviral medications. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of complex drug candidates targeting neurological pathways.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up GMP-compliant API manufacturing processes.
• Asymmetric Synthesis: Exploited for its defined stereocenters in the construction of other stereochemically complex molecules.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(3S,4As,8As)-Decahydro-n-(2-Hydroxy-1,1-Dimethylethyl)-3-Isoquinolinecarboxamide
CAS No.	213135-54-7
Molecular Formula	C₁₆H₂₈N₂O₂
Molecular Weight	280.41 g/mol
Synonyms	(3S,4aS,8aS)-Decahydro-N-(2-hydroxy-1,1-dimethylethyl)-3-isoquinolinecarboxamide; (3S,4aS,8aS)-N-(2-Hydroxy-1,1-dimethylethyl)decahydro-3-isoquinolinecarboxamide; Decahydro-N-(2-hydroxy-1,1-dimethylethyl)-3-isoquinolinecarboxamide (3S,4aS,8aS)-; UNII-9G8M9U6Q4F; 9G8M9U6Q4F; (3S,4aS,8aS)-N-(2-Hydroxy-2-methylpropyl)decahydroisoquinoline-3-carboxamide; A derivative of 3-Isoquinolinecarboxamide.
EINECS	Contact for details

Quality Control

Every batch of (3S,4As,8As)-Decahydro-n-(2-Hydroxy-1,1-Dimethylethyl)-3-Isoquinolinecarboxamide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and strength, meeting the exacting standards required for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) including results for chiral purity, assay, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.