Description

1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Methyl Ester Hydrochloride is a high-purity pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in its role as a key precursor for the development of complex molecules, particularly in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-quality intermediates for API synthesis and novel compound libraries.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular systems.
• Medicinal Chemistry Research: Used in the discovery and development of new drug candidates, especially as a core scaffold for alkaloid-like compounds.
• Fine Chemical Synthesis: Serves as a versatile precursor for creating complex heterocyclic compounds and specialty chemicals.
• Agrochemical Development: Employed in the research and synthesis of novel pesticides and herbicides.
• Academic & R&D Laboratories: Utilized in organic synthesis studies and for creating custom chemical libraries.
• Process Chemistry: Acts as a starting material or intermediate in scale-up and optimization of chemical manufacturing processes.

Basic Information

Product Name	1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Methyl Ester Hydrochloride
CAS No.	212958-77-5
Molecular Formula	C12H15NO2·HCl
Molecular Weight	241.71 g/mol (Free base: 205.25 g/mol)
Synonyms	1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid methyl ester hydrochloride; Methyl 1,2,3,4-tetrahydro-1-isoquinolinecarboxylate hydrochloride; 1-Carbomethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1-Methoxycarbonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; THIQ-1-COOMe·HCl; 1,2,3,4-Tetrahydro-1-isoquinolinecarboxylic acid methyl ester HCl; Methyl tetrahydroisoquinoline-1-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO standards ensures a reliable supply of high-purity material for demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.