Description

Pyrrolidine-2,2,3,3,4,4,5,5-D8 is a deuterated analog of pyrrolidine, where eight hydrogen atoms are replaced with deuterium, a stable isotope of hydrogen. This high isotopic purity is critical for applications requiring minimal spectral interference and enhanced metabolic stability in research. It is primarily utilized by scientists in pharmaceutical R&D, analytical chemistry, and material science. The compound, identified by CAS No. 212625-79-1, serves as a valuable building block and internal standard.

Application

• Pharmaceutical Research & Development: Used as a deuterated building block in the synthesis of labeled drug candidates for pharmacokinetic, metabolic stability (DMPK), and mass spectrometry studies.
• Analytical Chemistry: Serves as an internal standard or reference material in quantitative NMR (qNMR), LC-MS, and GC-MS analyses to ensure accuracy and precision.
• Mechanistic Studies: Employed in reaction mechanism elucidation and kinetic isotope effect (KIE) studies due to the significant mass difference between hydrogen and deuterium.
• Material Science: Potential use in the development of organic electronic materials and polymers where deuterium substitution can alter physical properties like stability and conductivity.
• Spectroscopy: Acts as a solvent or shift reference in NMR spectroscopy, particularly for minimizing proton background signals.

Basic Information

Product Name	Pyrrolidine-2,2,3,3,4,4,5,5-D8
CAS No.	212625-79-1
Molecular Formula	C4D8N
Molecular Weight	80.17 g/mol
Synonyms	Perdeuterated Pyrrolidine; Pyrrolidine-d8; Tetramethyleneimine-d8; Azacyclopentane-d8; 1-Azacyclopentane-d8; Deuterated Pyrrolidine; Pyrrolidine (2,2,3,3,4,4,5,5-D8); Pyrrolidine-D8
EINECS	Contact for details

Quality Control

Every batch of Pyrrolidine-2,2,3,3,4,4,5,5-D8 is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR (¹H, ²H) and GC-MS to confirm identity and deuterium enrichment. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and strong alkaline/organic solvent nature, store in a cool, well-ventilated place, ideally at 2-8°C for long-term stability. Keep away from heat, sparks, and open flames. Containers must be kept tightly sealed to prevent evaporation and absorption of moisture or carbon dioxide from the air.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Deuterium Enrichment (²H NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.