Description

2-Acetonitrilthiophene-5-Carboxylic Acid Ethyl Ester is a high-value heterocyclic building block and pharmaceutical intermediate of significant importance in modern organic synthesis. Its core value lies in its versatile molecular structure, which serves as a key precursor for the development of complex active pharmaceutical ingredients (APIs) and advanced materials. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in innovative drug discovery and fine chemical production.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides and herbicides, leveraging its thiophene core for bioactive molecule design.
• Material Science Research: Serves as a monomer or precursor for conducting polymers and organic electronic materials due to the conjugated thiophene system.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions and as a ligand precursor in catalytic systems for constructing complex molecular architectures.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry programs, enabling structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-Acetonitrilthiophene-5-Carboxylic Acid Ethyl Ester
CAS No.	212508-31-1
Molecular Formula	C10H9NO2S
Molecular Weight	207.25 g/mol
Synonyms	Ethyl 2-(Cyanomethyl)thiophene-5-carboxylate; 5-(Ethoxycarbonyl)thiophene-2-acetonitrile; 2-(Cyanomethyl)-5-(ethoxycarbonyl)thiophene; Thiophene-5-carboxylic acid, 2-(cyanomethyl)-, ethyl ester; 2-Cyanomethyl-5-ethoxycarbonylthiophene
EINECS	Contact for details

Quality Control

Our 2-Acetonitrilthiophene-5-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, and we support our clients' regulatory submission needs with reliable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.