Description

Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-Fluoro-, (1S,2S,4S)- (9Ci) is a high-value, stereochemically defined fluorinated building block essential for advanced organic synthesis. This compound matters for its unique structural framework, combining the rigidity of a norbornene system with a strategically placed fluorine atom and a carboxylic acid handle, enabling precise molecular construction. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by specialty chemical manufacturers developing advanced materials and ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the design and synthesis of advanced crop protection agents, where the fluorine atom and rigid bicyclic structure can enhance biological activity and environmental stability.
• Catalyst & Ligand Development: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis to produce enantiomerically pure compounds.
• Advanced Material Research: Employed in polymer and material science to incorporate fluorinated, rigid moieties into specialty polymers, potentially altering their thermal, mechanical, or surface properties.
• Chemical Biology Probe Synthesis: Utilized as a building block for creating molecular probes and tools to study biological processes and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-Fluoro-, (1S,2S,4S)- (9Ci)
CAS No.	211444-70-1
Molecular Formula	C9H9FO2
Molecular Weight	168.16 g/mol
Synonyms	(1S,2S,4S)-2-Fluorobicyclo[2.2.1]hept-5-ene-2-carboxylic acid; endo-(1S,2S,4S)-2-Fluoro-5-norbornene-2-carboxylic acid; 2-Fluoro-5-norbornene-2-carboxylic acid, (1S,2S,4S)-; (1S,2S,4S)-2-Fluoro-2,3,3a,4,7,7a-hexahydro-1H-4,7-methanoinden-2-carboxylic acid; 2-Fluoro-2-norbornene-5-carboxylic acid, (1S,2S,4S)-; Fluorinated norbornene carboxylic acid derivative; Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 2-fluoro-, (1S-endo)-
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-Fluoro-, (1S,2S,4S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which could compromise product integrity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.