Description

9-Oxo-11Alpha,15S-Dihydroxy-Prost-13E-En-1-Oic-3,3,4,4-D4 Acid is a high-purity, deuterium-labeled analog of a key prostaglandin metabolite, offering exceptional value for research requiring precise isotopic tracing. This compound is critical for advanced analytical studies in pharmacology and biochemistry, where its stable isotope labeling provides unmatched accuracy in mass spectrometry and metabolic pathway analysis. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on lipid mediator research, drug metabolism, and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of prostaglandin and eicosanoid levels in biological matrices.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to elucidate the biosynthesis, turnover, and metabolic fate of prostanoids in in vitro and in vivo systems.
• Pharmaceutical R&D: Supports drug discovery and development programs targeting inflammatory pathways, enabling precise pharmacokinetic and pharmacodynamic studies of related compounds.
• Biomarker Research: Facilitates the development and validation of highly sensitive and specific clinical assays for inflammatory and oxidative stress biomarkers.
• Enzyme Activity Assays: Acts as a substrate or product analog in assays for enzymes involved in the arachidonic acid cascade, such as cyclooxygenases and prostaglandin dehydrogenases.
• Quality Control Reference: Employed as a certified reference material (CRM) for ensuring the accuracy and consistency of analytical methods in quality control laboratories.

Basic Information

Item	Details
Product Name	9-Oxo-11Alpha,15S-Dihydroxy-Prost-13E-En-1-Oic-3,3,4,4-D4 Acid
CAS No.	211105-33-8
Molecular Formula	C₂₀H₂₈D₄O₅
Molecular Weight	356.48 g/mol
Synonyms	11α,15S-Dihydroxy-9-oxoprost-13-en-1-oic-3,3,4,4-d4 Acid; Deuterated PGD2 Metabolite; 9,15-Dioxo-11α-hydroxy-2,3,4,5-tetranor-prostane-1,20-dioic-3,3,4,4-d4 Acid (d4); 9-Oxo-11α,15S-dihydroxy-prost-13E-en-1-oic-3,3,4,4-d4 Acid; d4-9-oxo-11α,15S-dihydroxy-prost-13E-en-1-oic Acid; Tetradeuterated 11α,15S-Dihydroxy-9-oxoprost-13-en-1-oic Acid; PGEM-d4; Deuterium Labeled Prostaglandin D2 Metabolite
EINECS	Contact for details

Quality Control

Every batch of 9-Oxo-11Alpha,15S-Dihydroxy-Prost-13E-En-1-Oic-3,3,4,4-D4 Acid is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR and high-resolution mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and confirming the absence of critical impurities. Our quality commitment ensures reliability for your most sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, containers should be sealed under an inert atmosphere and kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.