Description

9Alpha,15S-Dihydroxy-11-Oxo-Prosta-5Z,13E-Dien-1-Oic-3,3,4,4-D4 Acid is a high-purity, deuterium-labeled analog of a key prostaglandin metabolite, specifically designed for advanced research and analytical applications. This compound is critical for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic profiling in complex biological matrices. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and analytical laboratories focused on lipidomics, inflammation studies, and drug metabolism and pharmacokinetics (DMPK) research.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of endogenous prostaglandins and related eicosanoids in bioanalytical assays.
• Metabolomics & Lipidomics Research: Used as a stable isotope-labeled tracer to study arachidonic acid metabolism and inflammatory pathways.
• Drug Development & DMPK Studies: Supports pharmacokinetic studies by tracking drug-induced changes in prostaglandin levels.
• Clinical Biomarker Analysis: Enables reliable measurement of prostaglandin metabolites as potential biomarkers for inflammatory diseases in human plasma, serum, or urine samples.
• Reference Standard: Serves as a certified reference material for method development, validation, and quality control in analytical laboratories.

Basic Information

Product Name	9Alpha,15S-Dihydroxy-11-Oxo-Prosta-5Z,13E-Dien-1-Oic-3,3,4,4-D4 Acid
CAS No.	211105-29-2
Molecular Formula	C₂₀H₂₈D₄O₆
Molecular Weight	368.47 g/mol
Synonyms	9α,15S-Dihydroxy-11-oxoprosta-5Z,13E-dien-1-oic-3,3,4,4-d4 Acid; 11-Keto-d4-PGF2α; 11-Oxo-d4-PGF2α; Deuterated 11-oxo-Prostaglandin F2α; 9α,15S-Dihydroxy-11-oxo-13,14-dihydro-prosta-5Z-dien-1-oic-3,3,4,4-d4 Acid; 11-Keto-d4-PGF2α; PG metabolite d4 internal standard; 11-oxo-d4-PGF2α
EINECS	Contact for details

Quality Control

Our 9Alpha,15S-Dihydroxy-11-Oxo-Prosta-5Z,13E-Dien-1-Oic-3,3,4,4-D4 Acid is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS, to confirm chemical identity, isotopic purity (>98 atom % D), and chemical purity (typically >95%). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.