Description

Zonampanel CAS NO 210245-80-0 is a potent and selective competitive antagonist of the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) subtype of ionotropic glutamate receptors. This compound is of significant interest in advanced pharmaceutical research for its neuroprotective properties. It is primarily utilized by research institutions and pharmaceutical developers focused on central nervous system (CNS) disorders, including stroke, epilepsy, and neurodegenerative diseases.

Application

• Neuroscience Research: A critical tool for studying AMPA receptor function and glutamatergic signaling pathways in vitro and in vivo.
• Neuroprotective Agent Development: Serves as a reference compound and active pharmaceutical ingredient (API) in preclinical studies for conditions involving excitotoxicity, such as ischemic stroke.
• Epilepsy Research: Investigated for its potential to modulate neuronal hyperexcitability and seizure activity.
• Pharmacological Standard: Used as a high-purity analytical standard for method development and validation in bioanalytical laboratories.
• Drug Discovery Programs: A key intermediate or target molecule in medicinal chemistry efforts aimed at developing novel CNS therapeutics.
• Academic & Institutional Studies: Supports fundamental research into synaptic plasticity, learning, memory, and neurological disease mechanisms.

Basic Information

Product Name	Zonampanel
CAS No.	210245-80-0
Molecular Formula	C₁₅H₁₀N₄O₃
Molecular Weight	294.26 g/mol
Synonyms	Zonampanel; YM 90K; YM-90K; 6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione; 6-(Imidazol-1-yl)-7-nitro-1,2,3,4-tetrahydroquinoxaline-2,3-dione; AMPA receptor antagonist YM 90K; YM90K
EINECS	Contact for details

Quality Control

Our Zonampanel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.